-The game is set 10 years after Raccoon City, meaning it will be "present day" by the time it comes out.
-Chris Redfield is the main protagonist, now working for an organisation called the BSAA (as denoted by the patch on his uniform).
-BSAA's goals are unclear. Not known if Chris is fighting for good or evil.
-Events in Chris's past that took place between RE1 and RE5 will be broached.
-Lighting effects simulate the transition from light places to dark places, similar to how Half Life 2 used HDR.
-RE5's gameplay same as RE4's, plus extra features.
-A returning female character will be shown in the next trailer. She will feature heavily in the gameplay, i.e. be playable.
-Enemies are not Zombies or Ganados, but are in fact even more "human-like". My take on this is that they're the same as Ganados, except they can run.
rehorror.net